A family with Alzheimer disease (AD) has come to you for
help. They want to find the gene that is causing AD in their family.
They have already paid to have mutation testing done in known AD genes: amyloid precursor protein on chromosome 21, presenilin 1 on chromosome 14,
and presenilin 2 on chromosome 1. All of these tests have been
Their family doctor has tested them for the
apolipoprotein E gene (APOE), a risk factor that may lower the age of onset
of AD, and affected family members have genotypes with one or two E4
alleles. You decide that this family may be appropriate to study
in your research and draw blood from them to isolate their DNA. You check
online and find papers indicating that chromosomes 6, 10, and 12 may harbor
AD genes. You donít find any evidence that this family has chromosome
regions linked to AD on chromosomes 10 and 12. You then type markers
on chromosome six in this family. However, your assistant suddenly
and you have to run the analysis yourself. All you have to start with is a
pedigree, the marker genotypes, and a parameter file. You will have to
create the pedigree file yourself to finish the analyses.
Click Here to start your analyses.