A family with Alzheimer disease (AD) has come to you for help. They want to find the gene that is causing AD in their family.  They have already paid to have mutation testing done in known AD genes: amyloid precursor protein on chromosome 21, presenilin 1 on chromosome 14, and presenilin 2 on chromosome 1.  All of these tests have been negative.

Their family doctor has tested them for the apolipoprotein E gene (APOE), a risk factor that may lower the age of onset of AD, and affected family members have genotypes with one or two E4 alleles.  You decide that this family may be  appropriate to study in your research and draw blood from them to isolate their DNA. You check online and find papers indicating that chromosomes 6, 10, and 12 may harbor AD genes. You don’t find any evidence that this family has chromosome regions linked to AD on chromosomes 10 and 12.  You then type markers on chromosome six in this family.  However, your assistant suddenly quits and you have to run the analysis yourself. All you have to start with is a pedigree, the marker genotypes, and a parameter file. You will have to create the pedigree file yourself to finish the analyses.

Click Here to start your analyses.