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Part 3: Association Study

 

 

You're correct. The Odds ratio is 1.26:

 

Cases

Controls

Risk allele

a

b

Other alleles

c

d

Odds ratio = ad/bc

G->A intron substitution

AD patients

Controls

AG or AA

5

6

GG

33

50

 

Odds ratio = (5 x 50) / (33 x 6) = 1.26

95% Confidence Interval = .36 4.48

In this instance the confidence interval includes 1.  Therefore, the allele is not a significant risk factor for AD. 

LPA looked promising, but there might be a better candidate gene. 

 Click here to research more and try another one.