You're correct. The Odds ratio is 1.26:
|
|
Cases |
Controls |
|
Risk allele |
a |
b |
|
Other alleles |
c |
d |
Odds ratio = ad/bc
|
G->A intron substitution |
AD patients |
Controls |
|
AG or AA |
5 |
6 |
|
GG |
33 |
50 |
Odds ratio = (5 x 50) / (33 x 6) = 1.26
95% Confidence Interval = .36 – 4.48
In this instance the confidence interval includes 1. Therefore, the allele is not a significant risk factor for AD.
LPA looked promising, but there might be a better candidate gene.
Click here to research more and try another one.