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Part 3: Association Study

 

 

You're correct. The Odds ratio is 3.09:

 

Cases

Controls

Risk allele

a

b

Other alleles

c

d

Odds ratio = ad/bc

SOD2 C47T exon 2 Poly.

AD patients

Controls

TT or TC

21

16

CC

17

40

 

Odds ratio = (21 x 40) / (17 x 16) = 3.09

95% Confidence Interval = 1.30 7.32

In this instance the confidence interval is above 1.  Therefore, the T allele is a significant risk factor for AD. 

Good job!  You have discovered a gene on chromosome 6 that seems to be linked to Alzheimer disease.

Now, Click here to read more information on SOD2 to support your results.