Luckily in your lab, you had DNA from single cases of AD as well as some controls. You will use these to test genes in this region to see if you can find an AD associated gene.
Like any scientist, you must do some research before continuing your analysis. This will help you to choose appropriate candidate genes that are implicated in the pathogenic pathway of the disease. Look at the table below containing genes in your suspect region on chromosome 6q. Click on the OMIM number to open a new window to find out more information on each gene. Try to find one that may be associated with AD.
Genes between markers D6S1007 and D6S264
|
Gene |
Gene name |
OMIM # |
Location |
|
SNX9 |
SORTING NEXIN 9 |
||
|
TCTEL1 |
T-COMPLEX-ASSOCIATED TESTIS EXPRESSED 1-LIKE 1 |
||
|
VIL2 |
VILLIN 2 |
||
|
SOD2 |
SUPEROXIDE DISMUTASE 2 |
||
|
WTAP |
WILMS TUMOR 1-ASSOCIATING PROTEIN |
||
|
ACAT2 |
ACETYL-CoA ACETYLTRANSFERASE 2 |
||
|
TCP1 |
T-COMPLEX 1 |
||
|
MAS1 |
MAS1 ONCOGENE |
||
|
IGF2R |
INSULIN-LIKE GROWTH FACTOR II RECEPTOR |
||
|
SLC22A1 |
SOLUTE CARRIER FAMILY 22, MEMBER 1; |
||
|
SLC22A2 |
SOLUTE CARRIER FAMILY 22, MEMBER 2 |
||
|
SLC22A3 |
SOLUTE CARRIER FAMILY 22, MEMBER 3 |
||
|
LPA |
APOLIPOPROTEIN(a) |
||
|
PLG |
PLASMINOGEN |
||
|
MAP3K4 |
MITOGEN-ACTIVATED PROTEIN KINASE |
||
|
T |
T BRACHYURY, MOUSE, HOMOLOG OF |
||
|
PARK2 |
PARKIN |
Now, after your initial research, enter the name of one gene that you wish to study (name from first column: ie. VIL2). There may be more than one choice though as more than one gene could be associated with AD.